Applied network modelling

Data-driven network models can be applied to answer specific questions in experimental biology using genomic, transcriptomic and proteomic data. Collaborating with experimental researchers, I have developed network modelling approaches to guide experimental research in drug development¹¹ With colleagues at the Auckland Cancer Society Research Centre here and here, in signalling pathways in human skin²² With colleagues at the Auckland Bioengineering Institute here and here, and in neurochemistry³³ With colleagues at the Centre for Brain Research here.

Featured publications

Cursons J., Gao J., (Joint first authorship). Hurley D.G., Dunbar P.R., Jacobs M.D., Crampin E.J. Regulation of ERK-MAPK signaling in human epidermis. BMC Syst Biol. 2015;9(1):41.

Hunter, F. W., Jaiswal, J. K., Hurley, D. G., Liyanage, H. D., McManaway, S. P., Gu, Y., others. (2014). The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs. Biochemical Pharmacology, 89(2), 224–235.

Jansson, D., Rustenhoven, J., Feng, S., Hurley, D., Oldfield, R. L., Bergin, P. S., … Dragunow, M. (2014). A role for human brain pericytes in neuroinflammation. Journal of Neuroinflammation, 11(1), 104.

Wang, J., Guise, C. P., Hsu, H.-L., Hurley, D., Wilson, W. R., & Patterson, A. V. (2013). Identification of reductases capable of metabolic activation of hypoxia targeting prodrug SN30000 and hypoxia marker EF5. In Cancer Research (Vol. 73, pp. 2111–2111)